Arrest by ribosome
نویسندگان
چکیده
منابع مشابه
Ribosome pausing, arrest and rescue in bacteria and eukaryotes.
Ribosomes translate genetic information into polypeptides in several basic steps: initiation, elongation, termination and recycling. When ribosomes are arrested during elongation or termination, the cell's capacity for protein synthesis is reduced. There are numerous quality control systems in place to distinguish between paused ribosomes that need some extra input to proceed and terminally sta...
متن کاملMacrolide antibiotics allosterically predispose the ribosome for translation arrest.
Translation arrest directed by nascent peptides and small cofactors controls expression of important bacterial and eukaryotic genes, including antibiotic resistance genes, activated by binding of macrolide drugs to the ribosome. Previous studies suggested that specific interactions between the nascent peptide and the antibiotic in the ribosomal exit tunnel play a central role in triggering ribo...
متن کاملNascent SecM Chain Outside the Ribosome Reinforces Translation Arrest
SecM, a bacterial secretion monitor protein, contains a specific amino acid sequence at its C-terminus, called arrest sequence, which interacts with the ribosomal tunnel and arrests its own translation. The arrest sequence is sufficient and necessary for stable translation arrest. However, some previous studies have suggested that the nascent chain outside the ribosome affects the stability of ...
متن کاملDksA guards elongating RNA polymerase against ribosome-stalling-induced arrest.
In bacteria, translation-transcription coupling inhibits RNA polymerase (RNAP) stalling. We present evidence suggesting that, upon amino acid starvation, inactive ribosomes promote rather than inhibit RNAP stalling. We developed an algorithm to evaluate genome-wide polymerase progression independently of local noise and used it to reveal that the transcription factor DksA inhibits promoter-prox...
متن کاملBy ribosome possessed.
“Listen, howwould you like to come on tourwithmynewband?” BennyWilson asked me in the summer of 1965 duringmy final year of graduate school. A few days later, I received a letter from the National Institutes of Health (NIH) with the news that I had been awarded a three-year fellowship to do postdoctoral research at the Medical Research Council (MRC) Laboratory of Molecular Biology in Cambridge....
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ژورنال
عنوان ژورنال: Nature
سال: 2009
ISSN: 0028-0836,1476-4687
DOI: 10.1038/459046a